Indomethacin, prostaglandins, and schizophrenia.
نویسندگان
چکیده
منابع مشابه
Effects of prostaglandins and indomethacin on neuromuscular blocking agents.
The effects on neuromuscular blockade by d-tubocurarine and succinylcholine of inhibition of prostaglandin biosynthesis by indomethacin and of intra-arterial administration of prostoglandins E2 and F2 alpha, before and after inhibition of prostoglandin biosynthesis, were evaluated in the cat sciatic-tibialis preparation. Non-specific inhibition of prostaglandin biosynthesis by indomethacin 3 mg...
متن کاملModulation of the mitogenic response of lymphocytes from young and aged individuals by prostaglandins and indomethacin.
The effect of indomethacin (IND) on the mitogenic responses of human peripheral blood lymphocytes was dependent upon the dose of mitogen employed; in contrast, the effect of prostaglandins (PCs) was independent of the mitogen dose. When a single concentration of mitogen was used to study the effect of IND on blastogenesis, extremely variable results were observed, even among a healthy populatio...
متن کاملMouse cerebral prostaglandins, but not oxidative damage, change with age and are responsive to indomethacin treatment.
Epidemiological and clinical trial data indicate that at least some non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of developing Alzheimer's disease (AD). Advancing age is the most robust risk factor for AD. If NSAIDs mitigate the initiation of AD by affecting processes of aging, and if the target of NSAIDs are cyclooxygenases (COX), then COX activity would be hypothesized to in...
متن کاملEffects of indomethacin and prostaglandins on the dog iris sphincter and dilator muscles.
Effects of indomethacin and prostaglandins (PGs: PG E1, PG E2 and PG F2 alpha) on electrical and mechanical properties of the dog iris sphincter and dilator muscles were studied using isometric tension recording and microelectrode methods. When field stimulations (50 V, 0.4 msec, 10 stimuli at 10 Hz) were applied every 1 min, the muscle tone was gradually elevated in both muscle tissues. Applic...
متن کاملThe role of prostaglandins in the lower urinary tract dynamics of prostatectomized patients: a trial with indomethacin and aspirin.
Using 49 prostatectomized patients as experimental subjects, we studied the effects of Inclometnacin and acetylsalicylic acid — accredited prostaglandin synthetase inhibitors — from a urodynamic and clinical standpoint. Relevant urodynamic data was gathered 1 hr 30 mi after the patients had taken the drugs and placebo. Clinical results were further scrutinized after 8 days of treatment, at whic...
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ژورنال
عنوان ژورنال: BMJ
سال: 1977
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.6098.1357